Reconsideration of Lipotoxicity and the Metabolic Syndrome
نویسندگان
چکیده
منابع مشابه
Adipose tissue expandability, lipotoxicity and the metabolic syndrome.
E‐mail: [email protected] Whereas it is clear that obesity is a cardiovascular risk factor, the mechanisms linking expansion of the adipose tissue (AT) to these co-morbilities is uncertain. We think that inappropriate AT expandability and function is a key determinant of obesity-associated metabolic complications by initiating a lipotoxic proinflammatory cascade that affects essential metabolic o...
متن کاملClinical diagnosis of metabolic syndrome 2. Lipotoxicity as a mechanism of the metabolic syndrome.
Visceral fat obesity plays an essential role in the clustering of atherosclerotic multiple risk factors in the metabolic syndrome. However, the mechanism by which visceral fat obesity causes clustering of glucose intolerance, high blood pressure, and dyslipidemia remains unknown. We have proposed a “lipotoxicity theory” as the mechanism behind metabolic syndrome and its consequences: an excess ...
متن کاملVascular metabolic dysfunction and lipotoxicity.
The purpose of this study was to determine the role of lipotoxicity in vascular smooth muscle (VSM). C(1)-BODIPY 500/510 C(12) used to assess the ability of VSM A7r5 cells to transport long-chain fatty acids showed that lipid transport did not appear to limit metabolism. Thin layer chromatography revealed that storage of transported fatty acid occurred primarily as mono- and diglycerides and fa...
متن کاملRNA Regulation of Lipotoxicity and Metabolic Stress
Noncoding RNAs are an emerging class of nonpeptide regulators of metabolism. Metabolic diseases and the altered metabolic environment induce marked changes in levels of microRNAs and long noncoding RNAs. Furthermore, recent studies indicate that a growing number of microRNAs and long noncoding RNAs serve as critical mediators of adaptive and maladaptive responses through their effects on gene e...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oleoscience
سال: 2010
ISSN: 1345-8949
DOI: 10.5650/oleoscience.10.359